Cannabis has been used by humans for thousands of years and is one of the most popular drugs today. With effects such as feelings of joy and relaxation, it is also legal to prescribe or take in several countries.

But how does using the drug affect the mind? In three recent studies, published in The Journal of Psychopharmacology, Neuropsychopharmacology and the International Journal of Neuropsychopharmacology, we show that it can influence a number of cognitive and psychological processes.

The United Nations Office on Drugs and Crime reported that, in 2018, approximately 192 million people worldwide aged between 15 and 64 used cannabis recreationally. Young adults are particularly keen, with 35% of people between the ages of 18 and 25 using it, while only 10% of people over the age of 26 do.

This indicates that the main users are adolescents and young adults, whose brains are still in development. They may therefore be particularly vulnerable to the effects of cannabis use on the brain in the longer term.

Tetrahydrocannabinol (THC) is the main psychoactive compound in cannabis. It acts on the brain’s “endocannabinoid system”, which are receptors which respond to the chemical components of cannabis. The cannabis receptors are densely populated in prefrontal and limbic areas in the brain, which are involved in reward and motivation. They regulate signalling of the brain chemicals dopamine, gamma-aminobutyric acid (GABA) and glutamate.

We know that dopamine is involved in motivation, reward and learning. GABA and glutamate play a part in cognitive processes, including learning and memory.

Cognitive effects

Cannabis use can affect cognition, especially in those with cannabis-use disorder. This is characterised by the persistent desire to use the drug and disruption to daily activities, such as work or education. It has been estimated that approximately 10% of cannabis users meet the diagnostic criteria for this disorder.

In our research, we tested the cognition of 39 people with the disorder (asked to be clean on the day of testing), and compared it with that of 20 people who never or rarely used cannabis. We showed that participants with the condition had significantly worse performance on memory tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) compared to the controls, who had either never or very rarely used cannabis. It also negatively affected their “executive functions”, which are mental processes including flexible thinking. This effect seemed to be …….

Source: https://mercatornet.com/cannabis-how-it-affects-our-cognition-and-psychology/78611/

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